polars-bio

High-performance genomic interval operations and bioinformatics file I/O on Polars DataFrames. Overlap, nearest, merge, coverage, complement, subtract for BED/VCF/BAM/GFF intervals. Streaming, cloud-native, faster bioframe alternative.

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---
name: polars-bio
description: High-performance genomic interval operations and bioinformatics file I/O on Polars DataFrames. Overlap, nearest, merge, coverage, complement, subtract for BED/VCF/BAM/GFF intervals. Streaming, cloud-native, faster bioframe alternative.
license: https://github.com/biodatageeks/polars-bio/blob/main/LICENSE
metadata:
    skill-author: K-Dense Inc.
---

# polars-bio

## Overview

polars-bio is a high-performance Python library for genomic interval operations and bio
How to Use

Recommended: Install to project (local)

mkdir -p .claude/skills
curl -o .claude/skills/polars-bio.md \
  https://raw.githubusercontent.com/K-Dense-AI/claude-scientific-skills/main/scientific-skills/polars-bio/SKILL.md

Skill is scoped to this project only. Add .claude/skills/ to your .gitignoreif you don't want to commit it.

Alternative: Clone full repo

git clone https://github.com/K-Dense-AI/claude-scientific-skills

Then reference at scientific-skills/polars-bio/SKILL.md

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